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Several British studies have shown deficiencies in vitamins B1, B2, B6, B12, iron, or folic acid in a significant number of canker sore sufferers. Many readers have also e-mailed to say that they believe vitamin and mineral supplements have reduced the incidence or severity of their canker sores. Others, however, see no effect.

A good place to start is by seeing your doctor and having her take blood tests to measure your levels of B vitamins, folate, and other minerals. If you are deficient in any of these, your doctor can suggest appropriate supplements (It is not a good idea to take an excess of vitamins or minerals as toxicities can occur when you take too many).

Other readers have reported that a daily supplement of the amino acid lysine has dramatically reduced their occurences of canker sores. Please consult your physician for an appropriate daily dosage.

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